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Article

Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis.

Nature communications - 15 Jan 2021

Tak Uday, Dokland Terje, Niederweis Michael

Abstract excerpt

Mycobacterium tuberculosis secretes the tuberculosis necrotizing toxin (TNT) to kill host cells. Here, we show that the WXG100 proteins EsxE and EsxF are essential for TNT secretion. EsxE and EsxF form a water-soluble heterodimer (EsxEF) that assembles into oligomers and long filaments, binds to membranes, and forms stable membrane-spanning channels. Electron microscopy of EsxEF reveals mainly pentameric...

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Identifiers

PMID: 33452244
DOI: 10.1038/s41467-020-20533-1
PMCID: PMC7810871

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