Article

Deciphering the structural intricacy in virulence effectors for proton-motive force mediated unfolding and type-III protein secretion

2019-02-21

Abstract excerpt

<h4>ABSTRACT</h4> Many gram-negative pathogenic bacteria use type III secretion system (T3SS) to inject virulence effectors directly into the cytosol of targeted host cells. Given that the protein unfolding requisite for secretion via nano-size pore of T3SS injectisome is an energetically unfavorable process, “How do pathogenic bacteria unfold and secrete hundreds of toxic proteins in seconds” remain largely unkn...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5ba9bd29-5928-59de-a850-ce83a8560119
DOI: 10.1101/557496

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deciphering the structural intricacy in virulence effectors for proton-motive force mediated unfolding and type-III protein secretionDOI 10.1101/557496Read

Host-Derived Localized Acidification Triggers Chaperone-Primed Effector Unfolding at the T3SS GateSemantic proximity Read

Fueling type III secretion.Semantic proximity Read

A repulsive electrostatic mechanism for protein export through the type III secretion apparatus.Semantic proximity Read

Multiple driving forces required for efficient secretion of autotransporter virulence proteins.Semantic proximity Read

Mechanism of loading and translocation of type VI secretion system effector Tse6.Semantic proximity Read

Protein Export via the Type III Secretion System of the Bacterial FlagellumSemantic proximity Read

Identification of the MxiH needle protein residues responsible for anchoring invasion plasmid antigen D to the type III secretion needle tip.Semantic proximity Read

Intrinsic flexibility of Type VII secretion central pore is required for substrate translocationSemantic proximity Read

LcrH, a class II chaperone from the type three secretion system, has a highly flexible native structure.Semantic proximity Read

MxiA, MxiC and IpaD Regulate Substrate Selection and Secretion Mode in the T3SS of Shigella flexneri.Semantic proximity Read

Type VI Secretion Effectors: Methodologies and Biology.Semantic proximity Read

Large-scale discovery of candidate type VI secretion effectors with antibacterial activitySemantic proximity Read