Article
Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates.
Molecular cell - 12 Sept 2013
Silverman Julie M, Agnello Danielle M, Zheng Hongjin, Andrews Benjamin T, Li Mo, Catalano Carlos E, Gonen Tamir, Mougous Joseph D
Abstract excerpt
Secretion systems require high-fidelity mechanisms to discriminate substrates among the vast cytoplasmic pool of proteins. Factors mediating substrate recognition by the type VI secretion system (T6SS) of Gram-negative bacteria, a widespread pathway that translocates effector proteins into target bacterial cells, have not been defined. We report that haemolysin coregulated protein (Hcp), a ring-shaped hexamer...
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