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Article

NCX-Mediated Subcellular Ca2+ Dynamics Underlying Early Afterdepolarizations in LQT2 Cardiomyocytes.

Biophysical journal - 18 Sept 2018

Zhong Mingwang, Rees Colin M, Terentyev Dmitry, Choi Bum-Rak, Koren Gideon, Karma Alain

Abstract excerpt

Long QT syndrome type 2 (LQT2) is a congenital disease characterized by loss of function mutations in hERG potassium channels (IKr). LQT2 is associated with fatal ventricular arrhythmias promoted by triggered activity in the form of early afterdepolarizations (EADs). We previously demonstrated that intracellular Ca2+ handling is remodeled in LQT2 myocytes. Remodeling leads to aberrant late RyR-mediated Ca2+...

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Identifiers

PMID: 30173888
DOI: 10.1016/j.bpj.2018.08.004
PMCID: PMC6140381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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