Article

Pannexin 2 restrains ER stress-induced Ca <sup>2+</sup> dysregulation and inflammatory cardiomyocyte death

2026-01-28

Abstract excerpt

<h4>Background</h4> Endoplasmic reticulum (ER) stress and ER-mitochondria Ca 2+ dysregulation contribute to cardiomyocyte injury, yet endogenous regulators at ER-mitochondria interfaces that restrain this cascade remain poorly defined. Pannexin 2 (Panx2), the most structurally divergent pannexin isoform, has been implicated in stress response, but its cardiac localization and function are unclear. <h4>Methods</...

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Literature Corpus work: 9c7ea54f-d2f1-5c7e-adec-33db428e285f
DOI: 10.64898/2026.01.27.702168

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