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Article

Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies.

Circulation research - 30 Mar 2012

Tang Yijun, Tian Xixi, Wang Ruiwu, Fill Michael, Chen S R Wayne

Abstract excerpt

RATIONALE: Naturally occurring mutations in the cardiac ryanodine receptor (RyR2) have been associated with both cardiac arrhythmias and cardiomyopathies. It is clear that delayed afterdepolarization resulting from abnormal activation of sarcoplasmic reticulum Ca2+ release is the primary cause of...

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Share to Arrhythmogenic Right Ventricular Dysplasia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22374134
DOI: 10.1161/CIRCRESAHA.111.256560
PMCID: PMC3345272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22374134-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies.PMID 22374134Read ↗

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