Article
KCNE2 modulates cardiac L-type Ca(2+) channel.
Journal of molecular and cellular cardiology - 1 Jul 2014
Liu Wenjuan, Deng Jianxin, Wang Gang, Zhang Cuicui, Luo Xinping, Yan Dewen, Su Qingning, Liu Jie
Abstract excerpt
KCNE2 plays an important role in maintaining cardiac electrical stability. Mutations in KCNE2 have been linked to long-QT syndrome (LQT6) and atrial fibrillation/short QT syndrome. It has been suggested that KCNE2 has the most promiscuity of function which can interact with multiple-subunits of voltage-dependent cation channels and modulate their functions. However, whether KCNE2 regulates voltage-dependent...
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