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Article

Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin.

The Journal of physiology - 1 Jun 2000

Knollmann B C, Knollmann-Ritschel B E, Weissman N J, Jones L R, Morad M

Abstract excerpt

Overexpression of cardiac calsequestrin (CSQ) impairs Ca2+ signalling in murine myocytes, leading to marked cardiac hypertrophy. Here we report on contractile, histological and electrophysiological changes accompanying the development of cardiac hypertrophy and failure in CSQ-overexpressing mice. CSQ mice developed contractile dysfunction after 60 days of age, with only 40% survival at 6 months. Four- to...

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Identifiers

PMID: 10835049
DOI: 10.1111/j.1469-7793.2000.t01-1-00483.x
PMCID: PMC2269956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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