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Article

Calcium cycling in heart failure: the arrhythmia connection.

Journal of cardiovascular electrophysiology - 1 Jan 2002

Pogwizd Steven M, Bers Donald M

Abstract excerpt

Ventricular tachycardia in nonischemic heart failure (HF) arises from a nonreentrant mechanism most likely due to delayed afterdepolarizations from activation of a transient inward current (I(ti)). We present data and a paradigm in which an up-regulated Na/Ca exchanger, residual beta-adrenergic responsiveness, and decreased inward rectifying K current (I(K1)) in HF all conspire to markedly increase the propensity...

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Identifiers

PMID: 11843491
DOI: 10.1046/j.1540-8167.2002.00088.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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