Article
Development, Function, and Clinical Significance of Plasmacytoid Dendritic Cells in Chronic Myeloid Leukemia.
Cancer research - 1 Nov 2018
Inselmann Sabrina, Wang Ying, Saussele Susanne, Fritz Lea, Schütz Christin, Huber Magdalena, Liebler Simone, Ernst Thomas, Cai Dali, Botschek Sarah, Brendel Cornelia, Calogero Raffaele A, Pavlinic Dinko, Benes Vladimir, Liu Edison T, Neubauer Andreas, Hochhaus Andreas, Burchert Andreas
Abstract excerpt
Plasmacytoid dendritic cells (pDC) are the main producers of a key T-cell-stimulatory cytokine, IFNα, and critical regulators of antiviral immunity. Chronic myeloid leukemia (CML) is caused by BCR-ABL, which is an oncogenic tyrosine kinase that can be effectively inhibited with ABL-selective tyrosine kinase inhibitors (TKI). BCR-ABL-induced suppression of the transcription factor interferon regulatory factor 8...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.