Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1-mutated acute myeloid leukemia.

doi:10.1182/blood.2020007897

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Article

Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1-mutated acute myeloid leukemia.

Blood - 11 Mar 2021

Xiao Wenbin, Chan Alexander, Waarts Michael R, Mishra Tanmay, Liu Ying, Cai Sheng F, Yao Jinjuan, Gao Qi, Bowman Robert L, Koche Richard P, Csete Isabelle S, DelGaudio Nicole L, Derkach Andriy, Baik Jeeyeon, Yanis Sophia, Famulare Christopher A, Patel Minal, Arcila Maria E, Stahl Maximilian, Rampal Raajit K, Tallman Martin S, Zhang Yanming, Dogan Ahmet, Goldberg Aaron D, Roshal Mikhail, Levine Ross L

Abstract excerpt

Plasmacytoid dendritic cells (pDCs) are the principal natural type I interferon-producing dendritic cells. Neoplastic expansion of pDCs and pDC precursors leads to blastic plasmacytoid dendritic cell neoplasm (BPDCN), and clonal expansion of mature pDCs has been described in chronic myelomonocytic leukemia. The role of pDC expansion in acute myeloid leukemia (AML) is poorly studied. Here, we characterize patients...

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PMID: 32871587
DOI: 10.1182/blood.2020007897
PMCID: PMC7955409

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