Plasmacytoid dendritic cells proliferation associated with acute myeloid leukemia: phenotype profile and mutation landscape

doi:10.3324/haematol.2020.253740

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Plasmacytoid dendritic cells proliferation associated with acute myeloid leukemia: phenotype profile and mutation landscape

Haematologica - 1 Dec 2021

Zalmaï Loria, Viailly Pierre-Julien, Biichle Sabeha, Cheok Meyling, Soret Lou, Angelot-Delettre Fanny, Petrella Tony, Collonge-Rame Marie-Agnès, Seilles Estelle, Geffroy Sandrine, Deconinck Eric, Daguindau Etienne, Bouyer Sabrina, Dindinaud Elodie, Baunin Victor, Le Garff-Tavernier Magali, Roos-Weil Damien, Wagner-Ballon Orianne, Salaun Véronique, Feuillard Jean, Brun Sophie, Drenou Bernard, Mayeur-Rousse Caroline, Okamba Patricia, Dorvaux Véronique, Tichionni Michel, Rose Johann, Rubio Marie Thérèse, Jacob Marie Christine, Raggueneau Victoria, Preudhomme Claude, Saas Philippe, Ferrand Christophe, Adotevi Olivier, Roumier Christophe, Jardin Fabrice, Garnache-Ottou Francine, Renosi Florian

Abstract excerpt

Neoplasms involving plasmacytoid Dendritic Cells (pDCs) include Blastic pDC Neoplasms (BPDCN) and other pDC proliferations, where pDCs are associated with myeloid malignancies: most frequently Chronic MyeloMonocytic Leukemia (CMML) but also Acute Myeloid Leukemia (AML), hereafter named pDC-AML. We aimed to determine the reactive or neoplastic origin of pDCs in pDC-AML, and their link with the CD34+ blasts,...

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PMID: 33054115
DOI: 10.3324/haematol.2020.253740
PMCID: PMC8634182

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