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Leukemic mutation FLT3-ITD is retained in dendritic cells and disrupts their homeostasis leading to expanded Th17 frequency.

Frontiers in immunology - 1 Jan 2024

Flynn Patrick A, Long Mark D, Kosaka Yoko, Long Nicola, Mulkey Jessica S, Coy Jesse L, Agarwal Anupriya, Lind Evan F

Abstract excerpt

Dendritic cells (DC) are mediators between innate and adaptive immune responses to pathogens and tumors. DC development is determined by signaling through the receptor tyrosine kinase Fms-like tyrosine kinase 3 (FLT3) in bone marrow myeloid progenitors. Recently the naming conventions for DC phenotypes have been updated to distinguish between "Conventional" DCs (cDCs) and plasmacytoid DCs (pDCs). Activating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38495876
DOI: 10.3389/fimmu.2024.1297338
PMCID: PMC10943691

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