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Article

Substantial improvement of toyocamycin production in Streptomyces diastatochromogenes by cumulative drug-resistance mutations.

PloS one - 1 Jan 2018

Shentu Xu-Ping, Cao Zhen-Yan, Xiao Yin, Tang Gu, Ochi Kozo, Yu Xiao-Ping

Abstract excerpt

Toyocamycin is a member of the nucleoside antibiotic family and has been recognized as a promising fungicide for the control of plant diseases. However, low productivity of toyocamycin remains an important bottleneck in its industrial production. Therefore, dramatic improvements of strains for overproduction of toyocamycin are of great interest in applied microbiology research. In this study, we sequentially...

Topics

Bacterial Proteins
Culture Media
Drug Resistance, Bacterial
Gene Expression Regulation, Bacterial
Mutation
Scandium
Streptomyces
Toyocamycin

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30161195
DOI: 10.1371/journal.pone.0203006
PMCID: PMC6117005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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