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Article

A rational multi-target combination strategy for synergistic improvement of non-ribosomal peptide production

22 Feb 2025

Abstract excerpt

Non-ribosomal peptides (NRPs) are pharmaceutically important natural products that include numerous clinical drugs. However, the biosynthesis of these NRPs is intricately regulated and improving production through manipulation of multiple regulatory targets remains largely empirical. We here develop a screening-based, multi-target rational combination strategy and demonstrate its effectiveness in enhancing the...

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PMID: 39987186
DOI: 10.1038/s41467-025-57073-5

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