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Article

Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations.

Applied and environmental microbiology - 1 May 2008

Wang Guojun, Hosaka Takeshi, Ochi Kozo

Abstract excerpt

We recently described a new method to activate antibiotic production in bacteria by introducing a mutation conferring resistance to a drug such as streptomycin, rifampin, paromomycin, or gentamicin. This method, however, enhanced antibiotic production by only up to an order of magnitude. Working with Streptomyces coelicolor A3(2), we established a method for the dramatic activation of antibiotic production by the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18310410
DOI: 10.1128/AEM.02800-07
PMCID: PMC2394871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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