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Article

Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations.

Applied and environmental microbiology - 1 Apr 2001

Hu H, Ochi K

Abstract excerpt

We developed a novel approach for improving the production of antibiotic from Streptomyces coelicolor A3(2) by inducing combined drug-resistant mutations. Mutants with enhanced (1.6- to 3-fold-higher) actinorhodin production were detected at a high frequency (5 to 10%) among isolates resistant to streptomycin (Str(r)), gentamicin (Gen(r)), or rifampin (Rif(r)), which developed spontaneously on agar plates which...

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Identifiers

PMID: 11282646
DOI: 10.1128/AEM.67.4.1885-1892.2001
PMCID: PMC92810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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