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Article

Structural and functional analysis of the DEAF-1 and BS69 MYND domains.

PloS one - 1 Jan 2013

Kateb Fatiha, Perrin Helene, Tripsianes Konstantinos, Zou Peijian, Spadaccini Roberta, Bottomley Matthew, Franzmann Titus M, Buchner Johannes, Ansieau Stephane, Sattler Michael

Abstract excerpt

DEAF-1 is an important transcriptional regulator that is required for embryonic development and is linked to clinical depression and suicidal behavior in humans. It comprises various structural domains, including a SAND domain that mediates DNA binding and a MYND domain, a cysteine-rich module organized in a Cys(4)-Cys(2)-His-Cys (C4-C2HC) tandem zinc binding motif. DEAF-1 transcription regulation activity is...

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Identifiers

PMID: 23372760
DOI: 10.1371/journal.pone.0054715
PMCID: PMC3555993

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Source receipt: pubmed, retrieved 7 Sept 2026.

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