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Article

Cxxc Finger Protein 1 Positively Regulates GM-CSF-Derived Macrophage Phagocytosis Through Csf2rα-Mediated Signaling.

Frontiers in immunology - 1 Jan 2018

Hui Zhaoyuan, Zhou Lina, Xue Zhonghui, Zhou Lingfeng, Luo Yikai, Lin Feng, Liu Xia, Hong Shenghui, Li Wei, Wang Di, Lu Linrong, Wang Jianli, Wang Lie

Abstract excerpt

Macrophages have a defensive function against bacteria through phagocytosis and the secretion of cytokines. Histone modifications play an essential role in macrophage functions. Here, we report that Cxxc finger protein 1 (CFP1), a key component of the SETD1 histone methyltransferase complex, promoted the phagocytic and bactericidal activity of GM-CSF-derived macrophages. CFP1-deficient mice were more susceptible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30154795
DOI: 10.3389/fimmu.2018.01885
PMCID: PMC6102347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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