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Article

Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function.

The Journal of experimental medicine - 21 Oct 2013

Nakamura Atsushi, Ebina-Shibuya Risa, Itoh-Nakadai Ari, Muto Akihiko, Shima Hiroki, Saigusa Daisuke, Aoki Junken, Ebina Masahito, Nukiwa Toshihiro, Igarashi Kazuhiko

Abstract excerpt

Pulmonary alveolar proteinosis (PAP) results from a dysfunction of alveolar macrophages (AMs), chiefly due to disruptions in the signaling of granulocyte macrophage colony-stimulating factor (GM-CSF). We found that mice deficient for the B lymphoid transcription repressor BTB and CNC homology 2 (Bach2) developed PAP-like accumulation of surfactant proteins in the lungs. Bach2 was expressed in AMs, and...

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Identifiers

PMID: 24127487
DOI: 10.1084/jem.20130028
PMCID: PMC3804940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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