Article

RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils

2023-01-28

Abstract excerpt

<h4>ABSTRACT</h4> The transcription factor RUNX1 is mutated in familial platelet disorder with associated myeloid malignancies (FPDMM) and in sporadic myelodysplastic syndrome and leukemia. RUNX1 regulates inflammation in multiple cell types. Here we show that RUNX1 is required in granulocyte-monocyte progenitors (GMPs) to restrict the inflammatory response of neutrophils to toll-like receptor 4 (TLR4) signaling....

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Literature Corpus work: bc724162-d123-548c-b357-8f056146e08d
DOI: 10.1101/2023.01.27.525911

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