Article
The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity.
Cell host & microbe - 11 Feb 2015
Wilson Gillian J, Marakalala Mohlopheni J, Hoving Jennifer C, van Laarhoven Arjan, Drummond Rebecca A, Kerscher Bernhard, Keeton Roanne, van de Vosse Esther, Ottenhoff Tom H M, Plantinga Theo S, Alisjahbana Bachti, Govender Dhirendra, Besra Gurdyal S, Netea Mihai G, Reid Delyth M, Willment Janet A, Jacobs Muazzam, Yamasaki Sho, van Crevel Reinout, Brown Gordon D
Abstract excerpt
The interaction of microbes with pattern recognition receptors (PRRs) is essential for protective immunity. While many PRRs that recognize mycobacteria have been identified, none is essentially required for host defense in vivo. Here, we have identified the C-type lectin receptor CLECSF8 (CLEC4D, MCL) as a key molecule in anti-mycobacterial host defense. Clecsf8-/- mice exhibit higher bacterial burdens and...
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