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Article

GATA2 downregulation contributes to pro-inflammatory phenotype and defective phagocytosis of pulmonary macrophages in chronic obstructive pulmonary disease.

Aging - 7 Oct 2024

Shen Shaoran, Huang Qiqing, Liu Lele, Zou Xiaoli, Kang Tutu, Wu Jianqing

Abstract excerpt

Pulmonary macrophages from COPD patients are characterized by lower phagocytic and bactericidal activity whereas there is hypersecretion of pro-inflammatory cytokines. The prominent decline of GATA2 expression in pulmonary macrophages from COPD patients inspired us to figure out its role during COPD development. The expression levels of GATA2 were decreased in alveolar macrophages isolated from cigarette smoke...

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Share to ATP Binding Cassette Transporter 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GATA2 Transcription Factor

Share to Macrophages, Alveolar

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Share to Pulmonary Disease, Chronic Obstructive

Source

Open in PubMed Open full text

Identifiers

PMID: 39379099
DOI: 10.18632/aging.206129
PMCID: PMC11501382

Genes

GATA2
CS
ABCA1
GULP1
MEGF10
PACSIN1
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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