Article

RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection

2024-11-06

Abstract excerpt

RING1 is an E3 ligase component of the polycomb repressive complex 1 (PRC1) with known roles in chromatin regulation and cellular processes such as apoptosis and autophagy. However, its involvement in inflammation and pyroptosis needs to be better characterized. Here, we found that human RING1, but not RING2, promoted K48-linked ubiquitination of Gasdermin D (GSDMD) and acted as a negative regulator of pyroptosis...

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Identifiers and source

Literature Corpus work: 4280096f-0302-5950-aaf4-cc8d123324f9
DOI: 10.1101/2024.11.05.622030

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