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Article

The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.

Immunity - 14 Dec 2012

Maruyama Kenta, Fukasaka Masahiro, Vandenbon Alexis, Saitoh Tatsuya, Kawasaki Takumi, Kondo Takeshi, Yokoyama Kazunari K, Kidoya Hiroyasu, Takakura Nobuyuki, Standley Daron, Takeuchi Osamu, Akira Shizuo

Abstract excerpt

Jdp2 is an AP-1 family transcription factor that regulates the epigenetic status of histones. Previous in vitro studies revealed that Jdp2 is involved in osteoclastogenesis. However, the roles of Jdp2 in vivo and its pleiotropic functions are largely unknown. Here we generated Jdp2(-/-) mice and...

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Source

Identifiers

PMID: 23200825
DOI: 10.1016/j.immuni.2012.08.022

Genes

ATF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23200825-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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