Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation.

Immunity - 1 Jan 2003

Hock Hanno, Hamblen Melanie J, Rooke Heather M, Traver David, Bronson Roderick T, Cameron Scott, Orkin Stuart H

Abstract excerpt

We report essential roles of zinc finger transcription factor Gfi-1 in myeloid development. Gene-targeted Gfi-1(-/-) mice lack normal neutrophils and are highly susceptible to abscess formation by gram-positive bacteria. Arrested, morphologically atypical, Gr1(+)Mac1(+) myeloid cells expand with age in the bone marrow. RNAs encoding primary but not secondary or tertiary neutrophil (granulocyte) granule proteins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Bacterial Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bone Marrow Cells

Share to Growth Disorders

Share to Neutrophils

Share to Phagocytosis

Share to Respiratory Burst

Share to Zinc Fingers

Source

Identifiers

PMID: 12530980
DOI: 10.1016/s1074-7613(02)00501-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation.PMID 12530980Read ↗

Gfi-1 Oncoproteins in HematopoiesisSemantic proximity Read ↗

The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction.Semantic proximity Read ↗

Mouse models of neutropenia reveal progenitor-stage-specific defects.Semantic proximity Read ↗

Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation.Semantic proximity Read ↗

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formationSemantic proximity Read ↗

Gfi1 regulates miR-21 and miR-196b to control myelopoiesisSemantic proximity Read ↗

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.Semantic proximity Read ↗

Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.Semantic proximity Read ↗

Gfi1 integrates progenitor versus granulocytic transcriptional programming.Semantic proximity Read ↗

Gfi1–cells and circuits: unraveling transcriptional networks of development and diseaseSemantic proximity Read ↗

Transcription Factor GFI1B in Health and DiseaseSemantic proximity Read ↗

The GFI1 Gene Family: Evolution, Structure, and Its Role in Immune ResponsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.