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Article

Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation.

Immunity - 1 Jan 2003

Hock Hanno, Hamblen Melanie J, Rooke Heather M, Traver David, Bronson Roderick T, Cameron Scott, Orkin Stuart H

Abstract excerpt

We report essential roles of zinc finger transcription factor Gfi-1 in myeloid development. Gene-targeted Gfi-1(-/-) mice lack normal neutrophils and are highly susceptible to abscess formation by gram-positive bacteria. Arrested, morphologically atypical, Gr1(+)Mac1(+) myeloid cells expand with...

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Identifiers

PMID: 12530980
DOI: 10.1016/s1074-7613(02)00501-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12530980-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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