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A Novel CCCH-Zinc Finger Protein Family Regulates Proinflammatory Activation of Macrophages

5 Jan 2008

Abstract excerpt

Activated macrophages play an important role in many inflammatory diseases. However, the molecular mechanisms controlling macrophage activation are not completely understood. Here we report that a novel CCCH-zinc finger protein family, MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation. Northern blot analysis revealed that the...

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PMID: 18178554
DOI: 10.1074/jbc.m707861200

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