Article
Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy.
Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2018
Dietrich Karin, Baumgart Jan, Eshkind Leonid, Reuter Lea, Gödtel-Armbrust Ute, Butt Elke, Musheev Michael, Marini Federico, More Piyush, Grosser Tanja, Niehrs Christof, Wojnowski Leszek, Mathäs Marianne
Abstract excerpt
Hepatic induction in response to drugs and environmental chemicals affects drug therapies and energy metabolism. We investigated whether the induction is transmitted to the offspring. We injected 3-day- and 6-week-old F0 female mice with TCPOBOP, an activator of the nuclear receptor constitutive androstane receptor (CAR, NR1I3), and mated them 1-6 weeks afterward. We detected in the offspring long-lasting...
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