Article

Impact of neonatal activation of nuclear receptor CAR (Nr1i3) on <i>Cyp2</i> gene expression in adult mouse liver

2022-01-23

Abstract excerpt

Perinatal exposure to environmental chemicals is proposed to reprogram development and alter disease susceptibility later in life. Supporting this, neonatal activation of the nuclear receptor CAR (Nr1i3) by TCPOBOP induces persistent expression of mouse hepatic Cyp2 genes into adulthood, attributed to long-term epigenetic memory of the early life exposure [Hepatology (2012) 56:1499-1509]. Here, we confirm that th...

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Literature Corpus work: 521321be-5c80-547d-a8b8-c8520c39225c
DOI: 10.1101/2022.01.21.477223

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