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Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Male Rats Exposed to Aroclor 1221 and Vinclozolin.

Environmental health perspectives - 1 Dec 2024

Hilz Emily N, Gillette Ross, Thompson Lindsay M, Crews David, Gore Andrea C

Abstract excerpt

BACKGROUND: Increasing evidence supports an association of endocrine-disrupting chemical (EDC) exposures with adverse biological effects in humans and wildlife. Recent studies reveal that health consequences of environmental exposures may persist or emerge across generations. This creates a dual conundrum: that we are exposed to contemporary environmental chemicals overlaid upon the inheritance of our ancestors'...

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PMID: 39739410
DOI: 10.1289/EHP15684
PMCID: PMC11687611

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