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Article

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.

Nature medicine - 1 Sept 2018

Hunter Roger W, Hughey Curtis C, Lantier Louise, Sundelin Elias I, Peggie Mark, Zeqiraj Elton, Sicheri Frank, Jessen Niels, Wasserman David H, Sakamoto Kei

Abstract excerpt

Metformin is a first-line drug for the treatment of individuals with type 2 diabetes, yet its precise mechanism of action remains unclear. Metformin exerts its antihyperglycemic action primarily through lowering hepatic glucose production (HGP). This suppression is thought to be mediated through inhibition of mitochondrial respiratory complex I, and thus elevation of 5'-adenosine monophosphate (AMP) levels and...

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Identifiers

PMID: 30150719
DOI: 10.1038/s41591-018-0159-7
PMCID: PMC6207338

Genes

FBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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