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Article

Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet.

Cell reports - 28 Mar 2017

Woods Angela, Williams Jennet R, Muckett Phillip J, Mayer Faith V, Liljevald Maria, Bohlooly-Y Mohammad, Carling David

Abstract excerpt

AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in response to energy demand. We identified a mutation in the γ1 subunit (γ1D316A) that leads to activation of AMPK. We generated mice with this mutation to study the effect of chronic liver-specific activation of AMPK in vivo. Primary hepatocytes isolated from these mice have reduced gluconeogenesis and fatty acid synthesis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28355557
DOI: 10.1016/j.celrep.2017.03.011
PMCID: PMC5382239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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