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Article

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.

Molecular cell - 19 Oct 2017

Lopez-Mejia Isabel C, Lagarrigue Sylviane, Giralt Albert, Martinez-Carreres Laia, Zanou Nadège, Denechaud Pierre-Damien, Castillo-Armengol Judit, Chavey Carine, Orpinell Meritxell, Delacuisine Brigitte, Nasrallah Anita, Collodet Caterina, Zhang Lianjun, Viollet Benoît, Hardie D Grahame, Fajas Lluis

Abstract excerpt

The roles of CDK4 in the cell cycle have been extensively studied, but less is known about the mechanisms underlying the metabolic regulation by CDK4. Here, we report that CDK4 promotes anaerobic glycolysis and represses fatty acid oxidation in mouse embryonic fibroblasts (MEFs) by targeting the AMP-activated protein kinase (AMPK). We also show that fatty acid oxidation (FAO) is specifically induced by AMPK...

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Share to AMP-Activated Protein Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29053957
DOI: 10.1016/j.molcel.2017.09.034

Genes

CDK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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