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Article

Risk-reducing bilateral salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations.

The Cochrane database of systematic reviews - 24 Aug 2018

Eleje George U, Eke Ahizechukwu C, Ezebialu Ifeanyichukwu U, Ikechebelu Joseph I, Ugwu Emmanuel O, Okonkwo Onyinye O

Abstract excerpt

BACKGROUND: The presence of deleterious mutations in breast cancer 1 gene (BRCA1) or breast cancer 2 gene (BRCA2) significantly increases the risk of developing some cancers, such as breast and high-grade serous cancer (HGSC) of ovarian, tubal and peritoneal origin. Risk-reducing salpingo-oophorectomy (RRSO) is usually recommended to BRCA1 or BRCA2 carriers after completion of childbearing. Despite prior...

Topics

Adult
Breast Neoplasms
Female
Genes, BRCA1
Genes, BRCA2
Heterozygote
Humans
Mastectomy
Middle Aged
Mutation
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quality of Life

Salpingo-oophorectomy

Source

Open in PubMed Open full text

Identifiers

PMID: 30141832
DOI: 10.1002/14651858.CD012464.pub2
PMCID: PMC6513554

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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