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Article

Bilateral risk-reducing oophorectomy in BRCA1 and BRCA2 mutation carriers.

Journal of the National Comprehensive Cancer Network : JNCCN - 1 Feb 2006

Domchek Susan M, Stopfer Jill E, Rebbeck Timothy R

Abstract excerpt

Bilateral risk-reducing oophorectomy (BRRO) is widely used for cancer risk reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations. BRRO significantly reduces breast cancer risk by approximately 50% and ovarian cancer risk by 85% to 95%, but it may be accompanied by menopausal symptoms, impaired quality of life, and accelerated bone loss. Therefore, decisions regarding the timing of BRRO, the risks and...

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Source

Identifiers

PMID: 16451773
DOI: 10.6004/jnccn.2006.0017

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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