Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells.

doi:10.1073/pnas.1803725115

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Article

Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells.

Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2018

Ahmed Abu Shufian Ishtiaq, Dong Kunzhe, Liu Jinhua, Wen Tong, Yu Luyi, Xu Fei, Kang Xiuhua, Osman Islam, Hu Guoqing, Bunting Kristopher M, Crethers Danielle, Gao Hongyu, Zhang Wei, Liu Yunlong, Wen Ke, Agarwal Gautam, Hirose Tetsuro, Nakagawa Shinichi, Vazdarjanova Almira, Zhou Jiliang

Abstract excerpt

In response to vascular injury, vascular smooth muscle cells (VSMCs) may switch from a contractile to a proliferative phenotype thereby contributing to neointima formation. Previous studies showed that the long noncoding RNA (lncRNA) NEAT1 is critical for paraspeckle formation and tumorigenesis by promoting cell proliferation and migration. However, the role of NEAT1 in VSMC phenotypic modulation is unknown....

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Identifiers

PMID: 30139920
DOI: 10.1073/pnas.1803725115
PMCID: PMC6140535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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