Article
Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases.
Cells - 15 Dec 2022
Tang Hao-Yue, Chen Ai-Qun, Zhang Huan, Gao Xiao-Fei, Kong Xiang-Quan, Zhang Jun-Jie
Abstract excerpt
Vascular smooth muscle cells (VSMCs), the major cell type in the arterial vessel wall, have a contractile phenotype that maintains the normal vessel structure and function under physiological conditions. In response to stress or vascular injury, contractile VSMCs can switch to a less differentiated state (synthetic phenotype) to acquire the proliferative, migratory, and synthetic capabilities for tissue...
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