Article
Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2011
Davis-Dusenbery Brandi N, Wu Connie, Hata Akiko
Abstract excerpt
The phenotype of vascular smooth muscle cells (VSMCs) is dynamically regulated in response to various stimuli. In a cellular process known as phenotype switching, VSMCs alternate between a contractile and synthetic phenotype state. Deregulation of phenotype switching is associated with vascular disorders such as atherosclerosis, restenosis after angioplasty, and pulmonary hypertension. An important role for...
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