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Article

Human cardiac cis-regulatory elements, their cognate transcription factors, and regulatory DNA sequence variants.

Genome research - 1 Oct 2018

Lee Dongwon, Kapoor Ashish, Safi Alexias, Song Lingyun, Halushka Marc K, Crawford Gregory E, Chakravarti Aravinda

Abstract excerpt

Cis-regulatory elements (CRE), short DNA sequences through which transcription factors (TFs) exert regulatory control on gene expression, are postulated to be the major sites of causal sequence variation underlying the genetics of complex traits and diseases. We present integrative analyses, combining high-throughput genomic and epigenomic data with sequence-based computations, to identify the causal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30139769
DOI: 10.1101/gr.234633.118
PMCID: PMC6169896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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