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Article

Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys

14 Apr 2005

Abstract excerpt

Enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease and is sometimes associated with serious neurological disorders. In this study, an attempt was made to identify molecular determinants of EV71 attenuation of neurovirulence in a monkey infection model. An infectious cDNA clone of the virulent strain of EV71 prototype BrCr was constructed; temperature-sensitive (ts)...

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PMID: 15831951
DOI: 10.1099/vir.0.80784-0

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