Article
Extended HLA-G genetic diversity and ancestry composition in a Brazilian admixed population sample: Implications for HLA-G transcriptional control and for case-control association studies.
Human immunology - 1 Nov 2018
Oliveira Maria Luiza Guimarães de, Veiga-Castelli Luciana Caricati, Marcorin Letícia, Debortoli Guilherme, Pereira Alison Luis Eburneo, Fracasso Nádia Carolina de Aguiar, Silva Guilherme do Valle, Souza Andréia S, Massaro Juliana Doblas, Simões Aguinaldo Luiz, Sabbagh Audrey, Donadi Eduardo Antônio, Castelli Erick C, Mendes-Junior Celso Teixeira
Abstract excerpt
Human leukocyte antigen-G (HLA-G) is a nonclassical Major Histocompatibility Complex (MHC) molecule with immunomodulatory function and restricted tissue expression. The genetic diversity of HLA-G has been extensively studied in several populations, however, the segment located upstream -1406 has not yet been evaluated. We characterized the nucleotide variation and haplotype structure of an extended distal region...
Topics
- 3' Untranslated Regions
- Brazil
- Computational Biology
- Ethnicity
- Gene Expression Regulation
- Genetic Variation
- Genetics, Population
- HLA-G Antigens