Article

Non-linear Age-related Change in Human Interleukin-11 and the receptor subunit alpha DNA Methylation

2025-04-08

Abstract excerpt

<h4>Introduction</h4> Interleukin-11 (IL-11) is a cytokine involved in inflammatory processes and a previous study showed that blocking or knocking down IL11 in mice prolongs a healthy lifespan. This study investigates DNA methylation (DNAm) changes in the IL11 and IL-11 receptor subunit alpha (IL-11RA) gene across ages to reveal how aging might influence IL-11 production and sensitivity. <h4>Methods</h4> A g...

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Literature Corpus work: 19ec3449-c897-5e02-88d4-592ce517082d
DOI: 10.1101/2025.04.01.646733

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