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Article

CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.

PloS one - 1 Jan 2013

Belot Marie-Pierre, Fradin Delphine, Mai Nga, Le Fur Sophie, Zélénika Diana, Kerr-Conte Julie, Pattou François, Lucas Bruno, Bougnères Pierre

Abstract excerpt

None of the polymorphic variants of the IL2RA gene found associated with Type 1 Diabetes (T1D) was shown to have a functional effect. To test if the epigenetic variation could play a role at this locus, we studied the methylation of 6 CpGs located within the proximal promoter of IL2RA gene in 252 T1D patients compared with 286 age-matched controls. We found that DNA methylation at CpGs -373 and -456 was slightly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23874506
DOI: 10.1371/journal.pone.0068093
PMCID: PMC3709990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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