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Hypermethylation of IL‐10 gene is responsible for its low mRNA expression in Behçet's disease

2 May 2018

Abstract excerpt

Interleukin-10 (IL-10), produced generally by monocyte, T helper type 2 (Th2), and regulatory T cells (Treg), plays a central role in controlling inflammatory responses and regulating the immune response of the IL-10 mRNA expression. It is significantly down-regulated in many autoimmune diseases such as Behçet's disease; this is mostly associated with more aggressive complications. Nevertheless, the essential...

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PMID: 29719061
DOI: 10.1002/jcb.26809

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