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Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation

1 Oct 2021

Abstract excerpt

To gain insight into the signaling determinants of effector-associated DNA methylation programming among CD8 T cells, we explore the role of interleukin (IL)-12 in the imprinting of IFNg expression during CD8 T cell priming. We observe that anti-CD3/CD28-mediated stimulation of human naive CD8 T cells is not sufficient to induce substantial demethylation of the IFNg promoter. However, anti-CD3/CD28 stimulation in...

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PMID: 34644568
DOI: 10.1016/j.celrep.2021.109796

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