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Article

In-vitro characterization of novel and functional regulatory SNPs in the promoter region of IL2 and IL2R alpha in a Gabonese population.

BMC medical genetics - 7 Dec 2012

Huang Xiangsheng, Kühne Vera, Kun Jürgen F J, Soboslay Peter T, Lell Bertrand, Tp Velavan

Abstract excerpt

BACKGROUND: The selection pressure imposed by the parasite has a functional consequence on the immune genes, leading to altered immune function in which regulatory T cells (Tregs) induced by parasites during infectious challenges modulate or thwart T effector cell mechanism. METHODS: We identified and investigated regulatory polymorphisms in the immune gene IL2 and its receptor IL2R alpha (also known as CD25) in...

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PMID: 23217119
DOI: 10.1186/1471-2350-13-117
PMCID: PMC3564939

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EBP
TBP

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