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Aberrantly methylated DNA regions lead to low activation of CD4+ T-cells in IgA nephropathy

4 Feb 2016

Abstract excerpt

IgAN (IgA nephropathy) is the most common form of primary glomerulonephritis worldwide and has a strong genetic component. In this setting, DNA methylation could also be an important factor influencing this disease. We performed a genome-wide screening for DNA methylation in CD4(+) T-cells from IgAN patients and found three regions aberrantly methylated influencing genes involved in the response and proliferation...

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PMID: 26846681
DOI: 10.1042/cs20150711

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