Article
Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naïve T Cells.
Frontiers in immunology - 1 Jan 2020
Guderud Kari, Sunde Line H, Flåm Siri T, Mæhlen Marthe T, Mjaavatten Maria D, Lillegraven Siri, Aga Anna-Birgitte, Evenrød Ida M, Norli Ellen S, Andreassen Bettina K, Franzenburg Sören, Franke Andre, Haavardsholm Espen A, Rayner Simon, Gervin Kristina, Lie Benedicte A
Abstract excerpt
Background: Differences in DNA methylation have been reported in B and T lymphocyte populations, including CD4+ T cells, isolated from rheumatoid arthritis (RA) patients when compared to healthy controls. CD4+ T cells are a heterogeneous cell type with subpopulations displaying distinct DNA methylation patterns. In this study, we investigated DNA methylation using reduced representation bisulfite sequencing in...
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