Article

H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in paediatric high-grade glioma cells

2023-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Diffuse intrinsic pontine gliomas (DIPG) are deadly paediatric brain tumours, non-resectable due to brainstem localisation and diffusive growth. Patients with DIPG have a dismal prognosis of 9-12 months of survival with no effective therapy. Over 80% of DIPGs harbour a mutation in histone 3 (H3.3 or H3.1) resulting in a lysine to methionine substitution (H3K27M). H3K27M causes global epigenetic...

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Literature Corpus work: ce566183-fe6c-5490-adfc-40ec0dd7d7b1
DOI: 10.1101/2023.05.15.540760

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