Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Putting a halt on PRC2 in pediatric glioblastoma.

Nature genetics - 1 Jun 2013

Voigt Philipp, Reinberg Danny

Abstract excerpt

Two new studies show that the known histone H3 alteration p.Lys27Met in pediatric glioma leads to globally diminished trimethylation at histone H3 lysine 27. The mutant histone H3 acts as a selective inhibitor of the PRC2 chromatin-modifying complex by binding and presumably sequestering it, shed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Isocitrate Dehydrogenase
Share to Leukemia, Myeloid, Acute
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23715325
DOI: 10.1038/ng.2647

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23715325-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Putting a halt on PRC2 in pediatric glioblastoma.PMID 23715325Read ↗

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric GlioblastomaSemantic proximity Read ↗

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.Semantic proximity Read ↗

Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas.Semantic proximity Read ↗

Chromatin remodeling defects in pediatric and young adult glioblastoma: a tale of a variant histone 3 tail.Semantic proximity Read ↗

Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade GliomaSemantic proximity Read ↗

Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma.Semantic proximity Read ↗

Histone H3 mutations--a special role for H3.3 in tumorigenesis?Semantic proximity Read ↗

H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in paediatric high-grade glioma cellsSemantic proximity Read ↗

Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination.Semantic proximity Read ↗

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.Semantic proximity Read ↗

Histone H3 mutations in pediatric brain tumors.Semantic proximity Read ↗

Emerging Advances in Combinatorial Treatments of Epigenetically Altered Pediatric High-Grade H3K27M GliomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.